Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety - Research Projects - Health Physics, Radiobiology & Cytogenetics

Research Projects

Research Projects - Health Physics, Radiobiology & Cytogenetics

The Health Physics, Radiobiology & Cytogenetics Laboratory lays emphasis on R&D activities in the areas of:

Radiobiology: Elucidation of the mechanisms underlying the biological effects of ionizing radiation. Genetic susceptibility to radiosensitivity and carcinogenesis.
Biodosimetry: Development of methodologies for absorbed dose and radiation risk estimation using chromosomal aberrations in human peripheral blood lymphocytes.
Radiation Protection: Development of cytogenetic methodologies to detect increased radiosensitivity and cancer proneness for evaluation of radiation accidents and the individualization of radiotherapy protocols.
Cytogenetics of hematological neoplasms: a) Identification of recurrent chromosome aberrations in Greek patients; b) Exploration of genomic rearrangements to uncover critical pathogenetic mechanisms.
Environmental Health: a) Characterization of genetic rearrangements following exposure to genotoxic agents; b) Inter-individual differences in disease susceptibility.

Recent R&D actions have been focused in the:

Development of a new cytogenetic methodology for the identification of persons with increased radiosensitivity and genetic predisposition to cancer, as well as for the individualization of radiation therapy protocols for cancer treatment.
Development of a new experimental methodology based on cell fusion and premature chromosome condensation for the investigation of radiation-induced cytogenetic effects in bystander non-irradiated cells (bystander effects).
Characterization of genomic rearrangements in hematologic neoplasms by modern molecular cytogenetic methodologies to unravel genetic mechanisms of leukemogenesis.
Identification of polymorphisms of detoxifying genes as predisposing factors a) for diseases of the nervous system and b) for the formation of certain specific chromosome aberrations in hematologic malignancies (e.g. exposure specific abnormalities).

Top