Development and validation of biomarkers using high throughput methodologies for assessing absorbed doses and health risk in case of radiation exposure emergencies, radiological accidents or terrorists acts.
Development of a cytokinesis–block micronucleus (CBMN) assay for measuring DNA damage, cytostasis and cytotoxicity induced by cytotoxic agents (ionizing radiation, drugs). Evaluation of induced radiosensitivity by various drugs.
Mechanistic insights on the aetiology of low-and high-LET radiation-induced chromosomal aberrations and risk for carcinogenesis using conventional and interphase cytogenetics.
Induction and repair kinetics of radiation-induced chromatid breaks during G2/M transition as a biological basis for predicting enhanced radiosensitivity and susceptibility to carcinogenesis at individual level.