Cytogenetics and molecular genetics of hematological malignancies

• Conventional (karyotype) and molecular (FISH) cytogenetic analyses of hematological malignancies for the identification and characterization of chromosomal abnormalities in hematologic malignancies.
• Characterization of genomic rearrangements in hematologic malignancies by molecular genetics for diagnosis, prognosis, treatment selection and follow up of the patients.
• Discrimination of early and late leukemia-associated genomic lesions in order to elucidate aberrations responsible for disease evolution.
• Investigation of polymorphisms of detoxifying and DNA repair genes as predisposing factors for the development of human malignancy.
• Epigenetic analysis of malignant hemopathies for the elucidation of genetic mechanisms involved in leukemogenesis.